EfficacyHigh
Studies12
Participants890
StatusAvailable
Semax
ACTH(4-10) Synthetic Analogue
Semax is a synthetic peptide analogue of ACTH(4-10) developed in Russia for cognitive enhancement and neuroprotection. It enhances BDNF expression, promotes neuroplasticity, and improves memory, attention, and cognitive processing speed while providing neuroprotective benefits against ischemic damage.
Clinical Safety Profile
Reported Side Effects
Mild nasal irritation
Occasional headache
Nasal congestion
Rare allergic reactions
Possible insomnia if taken late in day
Side Effect Management (Clinical Trial Data)
Mild Nasal Irritation
Occasional
12.4%
Nasal Congestion
Infrequent
8.1%
Occasional Headache
Infrequent
5.7%
Transient Insomnia
Infrequent
3.2%
Rare Allergic Reactions
Infrequent
1.1%
Side Effect Management Strategies
Nausea: Take with food, smaller meals, ginger supplements
Vomiting: Slower dose escalation, anti-emetics if severe
Diarrhea: Adequate hydration, probiotics, bland diet
Constipation: Increase fiber intake, adequate fluids, light exercise
Clinical Safety Metrics
Variable
Overall Safety Rating
Variable
Discontinuation Rate
Research
Approved Status
CONTRAINDICATIONS
• Known hypersensitivity to ACTH analogues
• Severe nasal obstruction or infection
• Pregnancy and breastfeeding
• Children under 18 years
Medical Disclaimer
Semax is a research chemical not approved by the FDA for human use in the United States. It is approved for medical use in Russia. All information is for educational purposes only. Consult with a qualified healthcare provider familiar with peptide therapy before considering use. Individual results may vary, and proper medical supervision is recommended for optimal safety and effectiveness.