Epithalon
L-alanyl-L-glutamyl-L-aspartyl-glycine
Epithalon is a synthetic tetrapeptide consisting of four amino acids (Ala-Glu-Asp-Gly) developed by Khavinson and colleagues in Russia during the late 1980s. With a molecular weight of 390.35 g/mol, this compact peptide mimics a segment of the naturally occurring thymic peptide epithalamin extracted from pineal glands, making it a valuable tool for research into telomere elongation, pineal gland function, and cellular aging processes in controlled experimental settings.
Clinical Benefits
Mechanism of Action
Epithalon likely activates telomerase in cell cultures, lengthening telomeres, and may enhance pineal melatonin synthesis in animal models, influencing circadian and HPA responses. The peptide appears to upregulate telomerase activity through unknown pathways, extending cellular replicative lifespan by preventing telomere shortening during cell division. Additionally, it modulates pineal gland function, potentially increasing melatonin production and regulating circadian rhythms, while also influencing the hypothalamic-pituitary-adrenal axis to reduce age-related stress responses.
Proven Results
Medical Disclaimer
Epithalon is an investigational research compound not approved by the FDA for human therapeutic use. This information is for educational purposes only and should not be construed as medical advice. Long-term safety data in humans is extremely limited.