HCG
Human Chorionic Gonadotropin
Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone naturally produced during pregnancy that mimics luteinizing hormone (LH) activity. It's FDA-approved for fertility treatments and hypogonadism in men. HCG stimulates testosterone production in males and triggers ovulation in females, making it valuable for hormone support, fertility preservation during testosterone therapy, and reproductive treatments.
Clinical Benefits
Mechanism of Action
HCG functions as a luteinizing hormone (LH) analog, binding with high affinity to the LH/chorionic gonadotropin receptor (LHCGR), a G-protein coupled receptor expressed primarily in gonadal tissues. Upon binding, it activates the Gs protein pathway, elevating intracellular cyclic adenosine monophosphate (cAMP) levels. This triggers protein kinase A (PKA) activation, leading to steroidogenesis through upregulation of steroidogenic acute regulatory (StAR) protein and enzymes like CYP11A1 and CYP17A1. In males, this results in testosterone synthesis by Leydig cells. In females, it induces ovulation and progesterone production by corpus luteum cells.
Proven Results
Medical Disclaimer
HCG is FDA-approved for specific fertility indications and testosterone replacement therapy support. This information is for educational purposes only and should not replace consultation with healthcare providers. Use only under medical supervision with appropriate monitoring.