GHK-Cu
Copper-GHK Tripeptide Complex
GHK-Cu is a naturally occurring copper peptide complex composed of the tripeptide glycyl-L-histidyl-L-lysine (GHK) bound to copper ions. Originally discovered in human plasma and wound healing processes, this bioactive peptide demonstrates remarkable regenerative properties through its ability to stimulate collagen synthesis, enhance angiogenesis, and modulate antioxidant enzyme activity. GHK-Cu is extensively researched for its anti-aging applications in skin health, wound healing, and hair growth, with over 30 years of clinical studies supporting its safety and efficacy.
Clinical Benefits
Mechanism of Action
GHK-Cu operates through multiple complementary pathways to promote tissue regeneration and combat aging. The copper ion acts as a cofactor for lysyl oxidase and lysyl hydroxylase, essential enzymes in collagen and elastin cross-linking. The peptide sequence (Gly-His-Lys) serves as a potent signaling molecule that activates transforming growth factor-β (TGF-β) pathways, stimulating fibroblast proliferation and collagen synthesis. Additionally, GHK-Cu enhances the activity of antioxidant enzymes including superoxide dismutase (SOD) and catalase, while modulating matrix metalloproteinase (MMP) expression to balance collagen degradation and synthesis. The complex also promotes angiogenesis through vascular endothelial growth factor (VEGF) upregulation and stimulates stem cell activity through activation of various growth factors.
Proven Results
Medical Disclaimer
GHK-Cu is used in cosmetic applications and research settings. This information is for educational purposes only and should not be construed as medical advice. Individual results may vary. Consult healthcare providers for appropriate skincare regimens.