PNC-27
PNC-27 (Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly)
PNC-27 is a synthetic 32-amino acid peptide specifically designed to bind to HDM-2 proteins expressed on cancer cell membranes. Through this selective targeting mechanism, PNC-27 induces the formation of transmembrane pores that disrupt cancer cell membrane integrity, leading to rapid cell lysis and death while sparing normal cells. With a molecular weight of 4,031.72 g/mol and the molecular formula C₁₈₈H₂₉₃N₅₃O₄₄S, PNC-27 represents a novel approach to cancer treatment that exploits the unique membrane expression of HDM-2 proteins in malignant cells. Research applications have demonstrated its effectiveness against multiple cancer types including pancreatic, breast, ovarian, melanoma, and leukemia cell lines.
PNC-27 Dosing Guide
Primary Benefits
- Selective targeting of HDM-2 protein on cancer cell membranes
- 95% cancer cell death rate across multiple cancer types
- Minimal cytotoxicity to normal cells lacking membrane HDM-2
- Effective against drug-resistant cancer cell lines
- Rapid onset of anticancer activity within 6-12 hours
How It Works
PNC-27 binds selectively to HDM-2 proteins expressed on cancer cell membranes through its targeting domain. Upon binding, the peptide induces formation of transmembrane pores that disrupt cellular membrane integrity and ion balance. This membrane disruption leads to rapid necrosis and lysis of cancer cells through osmotic shock and cellular depolarization. Normal cells remain unaffected due to minimal HDM-2 membrane expression.
Medical Disclaimer
Clinical data presented is from peer-reviewed studies. Individual results may vary. Consult healthcare professionals before starting treatment. This information is for educational purposes only.