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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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Melanotan-2
Tanning Effect85%
Studies4
Participants33
StatusOut of Stock

Melanotan-2

MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Melanotan-2 (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. Originally developed for skin pigmentation research, it has also been investigated for erectile dysfunction. NOT FDA approved and carries significant safety warnings from health agencies worldwide due to serious adverse effects including potential melanoma risk.

Clinical Benefits

Increases melanin production and skin pigmentation
Demonstrated efficacy in erectile dysfunction (8/10 responders in clinical studies)
May reduce appetite through MC4 receptor activation
Rapid onset of action (1-5 hours for sexual effects)
Long-lasting pigmentation effects
Potential sunburn protection through increased melanin

Mechanism of Action

Melanotan-2 functions as a non-selective agonist of melanocortin receptors (MC1, MC3, MC4, and MC5). Primary mechanism involves binding to MC1 receptors on melanocytes, activating adenylyl cyclase and increasing cyclic adenosine monophosphate (cAMP) levels. This leads to activation of protein kinase A (PKA) and phosphorylation of cAMP response element-binding protein (CREB), ultimately stimulating transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase, key enzymes in melanin synthesis. MC4 receptor activation in the central nervous system affects sexual behavior and appetite regulation through hypothalamic pathways, while MC3 receptor involvement may contribute to energy homeostasis effects.

Key Action:

Proven Results

%
Maximum Weight Loss
Clinical research data
0%
Diabetes Risk Reduction
Clinical research data
33
Total Participants
Research studies
0%
CV Risk Reduction
Clinical data

Medical Disclaimer

CRITICAL WARNING: Melanotan-2 is NOT approved by the FDA or any major regulatory agency for human use. Health authorities worldwide have issued warnings against its use due to serious safety risks including potential melanoma, priapism, rhabdomyolysis, and systemic toxicity. This information is for educational and research purposes only. Any use requires medical supervision and carries significant legal and health risks. Consult healthcare providers for approved alternatives.