
MOTS-C
Mitochondrial Open Reading Frame of the 12S rRNA-c
MOTS-C is a 16-amino acid mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA. It plays a crucial role in regulating metabolic homeostasis, glucose metabolism, and insulin sensitivity. MOTS-C has shown promising therapeutic potential in aging, diabetes management, cardiovascular health, and physical performance enhancement. Currently in research phase with no clinical approval.
Clinical Benefits
Mechanism of Action
MOTS-C functions as a mitochondrial-nuclear communication peptide that activates AMP-activated protein kinase (AMPK) signaling pathways. It modulates the folate/methionine cycle and enhances cellular stress resistance. MOTS-C interacts with nuclear genes to regulate metabolic homeostasis, particularly glucose metabolism and insulin sensitivity. The peptide promotes mitochondrial biogenesis, improves oxidative metabolism, and provides cytoprotection against age-related cellular damage.
Proven Results
Medical Disclaimer
MOTS-C is an experimental peptide not approved by the FDA for therapeutic use. It is banned by WADA for athletic competition. All information is for educational purposes only and should not constitute medical advice. Consult healthcare professionals before considering any peptide therapy. Long-term safety and efficacy in humans remain unknown.