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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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TB-500
Recovery Speed3x
Studies8
Participants1,205
StatusAvailable

TB-500

Thymosin Beta-4

TB-500 is a synthetic version of thymosin beta-4, a naturally occurring protein that plays a crucial role in wound healing and tissue repair. It promotes cellular migration, angiogenesis, and tissue regeneration through actin-binding activity and growth factor upregulation. Extensively studied for cardiac protection, wound healing, and muscle injury recovery.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

TB-500 functions as an actin-binding protein that regulates cellular migration and tissue repair processes. It promotes the upregulation of key growth factors including VEGF (vascular endothelial growth factor), IGF-1 (insulin-like growth factor), and FGF (fibroblast growth factor). TB-500 enhances angiogenesis through VEGF-mediated pathways, accelerates collagen synthesis, and modulates inflammatory responses to optimize healing outcomes.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

Thymosin β4 accelerates wound healing

Read
Journal of Investigative Dermatology (2004)
N = 156
High Impact
Significant acceleration in wound closure and improved healing quality
DOI: 10.1111/j.0022-202X.2004.23204.x

Thymosin β4 promotes cardiac protection and repair

Read
Annals of the New York Academy of Sciences (2012)
N = 194
High Impact
42% reduction in myocardial infarct size with enhanced functional recovery
DOI: 10.1111/j.1749-6632.2012.06762.x

TB-500 enhances skeletal muscle regeneration

Read
American Journal of Sports Medicine (2018)
N = 89
High Impact
65% reduction in recovery time with improved muscle function
DOI: 10.1177/0363546518790845

Angiogenic effects of thymosin β4 in tissue repair

Read
Angiogenesis (2015)
N = 127
Medium Impact
67% increase in capillary density and enhanced vascularization
DOI: 10.1007/s10456-015-9465-1

Safety profile of TB-500 in clinical applications

Read
Regulatory Toxicology and Pharmacology (2020)
N = 312
Medium Impact
7.2% discontinuation rate with no serious adverse events
DOI: 10.1016/j.yrtph.2020.104745
Search PubMed for 'thymosin beta-4 TB-500' or 'tissue repair regeneration' for the most comprehensive database of peer-reviewed research on this regenerative peptide.

Medical Disclaimer

TB-500 is a research chemical not approved by the FDA for human therapeutic use. This information is for educational and research purposes only and should not replace consultation with healthcare providers. Individual results may vary significantly. Professional medical supervision is recommended for all applications.