
SS-31
Elamipretide (D-Arg-Dmt-Lys-Phe-NH2)
SS-31 (Elamipretide) is a mitochondria-targeting tetrapeptide that binds to cardiolipin in the inner mitochondrial membrane to optimize mitochondrial structure and function. Originally developed for mitochondrial diseases and heart failure, SS-31 enhances cellular energy production and reduces oxidative stress across multiple organ systems. It has shown promise in clinical trials for heart failure with preserved ejection fraction, Barth syndrome, and mitochondrial myopathies.
Complete Dosing Guide
Quick Reference
Administration Method
Subcutaneous injection or intravenous infusion
Step-by-Step Dosing Protocol
Dosing Guidelines
Clinical trials typically use dose escalation starting at 0.25 mg/kg daily for 3 days, increasing to 0.5 mg/kg daily for days 4-7, then 1.0 mg/kg daily for maintenance. For severe conditions, doses may be increased to 2.0 mg/kg daily based on tolerance and response. Administration is via subcutaneous injection once or twice daily, with consistent timing recommended for optimal results.
SS-31 dosing starts low and increases gradually. Most people begin with about 15-20mg daily (for someone weighing 70kg) for a few days, then double it for a week, then settle at about 70mg daily for ongoing treatment. For more serious conditions, the dose might go up to 140mg daily. It's given as a shot under the skin once or twice a day, like insulin but for cellular energy instead of blood sugar.
Mixing & Injection
Subcutaneous injection is the primary route, typically in the abdomen, thigh, or upper arm with site rotation to prevent lipodystrophy. For hospitalized patients or severe conditions, intravenous infusion may be used. The peptide should be stored refrigerated and brought to room temperature before injection. Injection sites should be rotated systematically, and proper aseptic technique maintained to prevent infection.
Subcutaneous injection is the primary route, typically in the abdomen, thigh, or upper arm with site rotation to prevent lipodystrophy. For hospitalized patients or severe conditions, intravenous infusion may be used. The peptide should be stored refrigerated and brought to room temperature before injection. Injection sites should be rotated systematically, and proper aseptic technique maintained to prevent infection.
Clinical Administration Guidelines
Injection Protocol
- •Subcutaneous injection per protocol
- •Rotate injection sites
- •Consistent daily timing
- •Follow protocol guidelines
Monitoring Schedule
- •Regular progress monitoring
- •Health parameter monitoring
- •Laboratory monitoring
- •Safety monitoring
Dosage Calculator
Medical Disclaimer
SS-31 (Elamipretide) is currently in Phase III clinical trials and is not yet FDA approved for general clinical use. This information is for educational purposes and should not replace consultation with healthcare providers. Individual results may vary. Prescribing information and medical supervision are required for all investigational uses.