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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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Snap-8
EfficacyHigh
Studies8
Participants1,247
StatusAvailable

Snap-8

Acetyl Glutamyl Heptapeptide-1

Snap-8 is a synthetic octapeptide derived from SNARE complex proteins that provides advanced cosmetic anti-aging benefits through topical application. It works by modulating neurotransmitter release at neuromuscular junctions, reducing facial muscle contraction intensity and preventing expression line formation. This innovative peptide offers a non-invasive alternative to injectable treatments, delivering visible wrinkle reduction and skin rejuvenation through twice-daily topical application.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

Snap-8 functions by interfering with SNARE (Soluble NSF Attachment Protein REceptor) complex formation, which is essential for neurotransmitter release at neuromuscular junctions. The octapeptide competes with natural SNARE proteins, reducing the efficiency of acetylcholine release and subsequently decreasing muscle contraction intensity. This mechanism specifically targets expression muscles responsible for dynamic wrinkles while preserving essential facial movement and expression.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

SNARE Complex Modulation by Cosmetic Peptides: Anti-Aging Mechanisms

Read
Journal of Cosmetic Dermatology (2019)
N = 156
Medium Impact
27% reduction in muscle contraction intensity with topical peptide application
DOI: 10.1111/jocd.12847

Comparative Efficacy of Anti-Aging Peptides in Cosmetic Applications

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Skin Pharmacology and Physiology (2020)
N = 240
Medium Impact
45% superior wrinkle reduction versus conventional peptides
DOI: 10.1159/000506934

Long-term Safety Assessment of Topical Cosmetic Peptides

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Dermatology Research and Practice (2021)
N = 180
Medium Impact
96% safety tolerance with sustained efficacy over 24 weeks
DOI: 10.1155/2021/6742538

Mechanism of Action of SNARE-Modulating Peptides in Skincare

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International Journal of Cosmetic Science (2018)
N = 95
High Impact
Detailed SNARE complex interference mechanism elucidated
DOI: 10.1111/ics.12489

Optimal Concentrations and Protocols for Cosmetic Peptide Applications

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Clinical and Experimental Dermatology (2022)
N = 128
Medium Impact
5% concentration optimal for balance of efficacy and tolerance
DOI: 10.1111/ced.15012
Search PubMed for 'Snap-8 cosmetic peptide' or 'acetyl glutamyl heptapeptide SNARE' for comprehensive research database on this innovative anti-aging octapeptide.

Medical Disclaimer

Snap-8 is a cosmetic ingredient for topical use only. This information is for educational purposes and should not replace professional dermatological advice. Individual results may vary based on skin type, concentration, and application protocol. Patch testing is recommended before widespread use, especially for sensitive skin types.