
Sermorelin
Sermorelin acetate (GHRH 1-29)
Sermorelin is a synthetic 29-amino acid peptide that mimics the biologically active portion of growth hormone releasing hormone (GHRH). Originally FDA-approved in 1997 as Geref® for treating children with growth hormone deficiency, it stimulates the pituitary gland to produce natural growth hormone in physiological pulsatile patterns. Unlike direct growth hormone injections, sermorelin works with the body's feedback mechanisms to prevent overdose and maintain natural GH rhythms.
Complete Dosing Guide
Quick Reference
Administration Method
Subcutaneous injection at bedtime on empty stomach
Step-by-Step Dosing Protocol
Dosing Guidelines
Standard sermorelin dosing follows a gradual escalation protocol starting at 100 mcg nightly for weeks 1-2 to assess tolerance, advancing to 200 mcg nightly (standard therapeutic dose) for weeks 3-4, with potential increase to 300 mcg nightly for enhanced response if needed. Maintenance dosing typically involves 200-300 mcg administered 5 nights per week with 2 non-consecutive rest days to prevent receptor downregulation. All doses are administered via subcutaneous injection 30 minutes before bedtime on an empty stomach (2+ hours after last meal). Pediatric dosing for FDA-approved use was weight-based at 30 mcg/kg daily. IGF-1 monitoring guides dose optimization.
Starting sermorelin is like learning to ride a bike - you begin slowly and work your way up! Most people start with a tiny dose (100 mcg) for the first two weeks, just to make sure their body handles it well. Then you move up to the standard dose (200 mcg) for most people. Some might need a bit more (300 mcg) for better results. Here's the key: inject it about 30 minutes before bed on an empty stomach - no food for at least 2 hours before. Most people take it 5 nights a week with 2 nights off (like weekends) to keep it working well. Your doctor will check your blood levels to make sure you're on the right dose.
Mixing & Injection
Sermorelin requires subcutaneous injection using 29-30 gauge insulin syringes into fatty tissue areas. Recommended injection sites include lower abdomen (2 inches from navel), anterior thigh, or posterior upper arm. Site rotation is essential to prevent lipodystrophy or injection site reactions. Proper injection technique involves pinching skin fold, inserting needle at 45-90 degree angle, aspirating to ensure no blood return, injecting slowly over 5-10 seconds, and applying gentle pressure post-injection. Reconstitution requires sterile bacteriostatic water, gentle mixing to avoid foam formation, and immediate refrigeration. Each vial typically provides 30-day supply when properly stored.
Sermorelin requires subcutaneous injection using 29-30 gauge insulin syringes into fatty tissue areas. Recommended injection sites include lower abdomen (2 inches from navel), anterior thigh, or posterior upper arm. Site rotation is essential to prevent lipodystrophy or injection site reactions. Proper injection technique involves pinching skin fold, inserting needle at 45-90 degree angle, aspirating to ensure no blood return, injecting slowly over 5-10 seconds, and applying gentle pressure post-injection. Reconstitution requires sterile bacteriostatic water, gentle mixing to avoid foam formation, and immediate refrigeration. Each vial typically provides 30-day supply when properly stored.
Clinical Administration Guidelines
Injection Protocol
- •Subcutaneous injection per protocol
- •Rotate injection sites
- •Consistent daily timing
- •Follow protocol guidelines
Monitoring Schedule
- •Regular progress monitoring
- •Health parameter monitoring
- •Laboratory monitoring
- •Safety monitoring
Dosage Calculator
Medical Disclaimer
Clinical data presented is from peer-reviewed studies. Individual results may vary. Consult healthcare professionals before starting treatment. This information is for educational purposes only.