Semaglutide

Semaglutide requires careful dose escalation to minimize gastrointestinal side effects. For diabetes (Ozempic): start 0.25mg weekly for 4 weeks, increase to 0.5mg weekly, with optional escalation to 1.0mg weekly if additional glycemic control needed. For weight management (Wegovy): initiate 0.25mg weekly for 4 weeks, escalate to 0.5mg for 4 weeks, then 1.0mg for 4 weeks, 1.7mg for 4 weeks, and finally 2.4mg for maintenance. Oral formulation (Rybelsus) starts at 3mg daily for 30 days, increasing to 7mg daily, with possible escalation to 14mg daily. Injections should be administered same day each week, rotating between abdomen, thigh, or upper arm. Critical monitoring includes monthly weight tracking, quarterly HbA1c for diabetics, and biannual comprehensive metabolic panels.

Semaglutide requires a gradual 'step-up' approach because jumping to full dose would cause severe nausea for most people. Think of it like training for a marathon - you start slow and build up. For weight loss, you start with a tiny dose (0.25mg) once a week for a month, then slowly increase every month until you reach the full dose (2.4mg) at month 5. Most people find the nausea gets better as their body adjusts to each new dose level. You inject it once a week on the same day - many people pick Sunday so they remember. The injection goes into fatty areas like your belly, thigh, or upper arm, and you rotate spots each week. The oral version is taken daily on an empty stomach first thing in the morning, which some people prefer over injections.

Semaglutide is administered via subcutaneous injection using pre-filled, single-use pens (FlexTouch for Ozempic and Wegovy) containing multiple doses. Inject into subcutaneous tissue of abdomen, thigh, or upper arm at a 90-degree angle using integrated needle. Prime pen before first use, dial appropriate dose, insert needle fully, press and hold injection button for 6 seconds after dose counter reaches 0. Rotate injection sites within chosen area to prevent lipodystrophy. Store pen in refrigerator between uses, allow to reach room temperature before injection. Oral formulation (Rybelsus) must be taken on empty stomach with ≤4 ounces water, waiting 30 minutes before food, drink, or other medications. Consistent weekly timing for injections optimizes therapeutic levels and reduces breakthrough symptoms.

Semaglutide is administered via subcutaneous injection using pre-filled, single-use pens (FlexTouch for Ozempic and Wegovy) containing multiple doses. Inject into subcutaneous tissue of abdomen, thigh, or upper arm at a 90-degree angle using integrated needle. Prime pen before first use, dial appropriate dose, insert needle fully, press and hold injection button for 6 seconds after dose counter reaches 0. Rotate injection sites within chosen area to prevent lipodystrophy. Store pen in refrigerator between uses, allow to reach room temperature before injection. Oral formulation (Rybelsus) must be taken on empty stomach with ≤4 ounces water, waiting 30 minutes before food, drink, or other medications. Consistent weekly timing for injections optimizes therapeutic levels and reduces breakthrough symptoms.

Injection Protocol

• •Subcutaneous injection per protocol
• •Rotate injection sites
• •Consistent daily timing
• •Follow protocol guidelines

Monitoring Schedule

• •Regular progress monitoring
• •Health parameter monitoring
• •Laboratory monitoring
• •Safety monitoring