PT-141

The FDA-approved dosing regimen for PT-141 is 1.75 mg administered subcutaneously via auto-injector at least 45 minutes before anticipated sexual activity. The maximum frequency is 8 injections per 30-day period, with no more than one dose per 24-hour period. No dose escalation or titration is required - the therapeutic dose is fixed at 1.75 mg. Pre-medication with anti-emetics may be considered for patients experiencing significant nausea, though tolerance typically develops after 2-3 uses.

PT-141 comes as a pre-filled auto-injector (like an EpiPen) that you give yourself under the skin. The dose is always the same - 1.75 mg - and you inject it at least 45 minutes before you want to be intimate. You can use it up to 8 times per month, but never more than once in 24 hours. Think of it like taking medicine for a headache - you use it when you need it, not every day.

PT-141 is administered via subcutaneous injection using the Vyleesi auto-injector device. Injection sites include the abdomen (avoiding 2 inches around navel) or anterior thigh. Site rotation is recommended to minimize injection site reactions. The auto-injector is single-use and pre-filled with 1.75 mg of bremelanotide. Patients should be trained on proper injection technique including site preparation with alcohol, perpendicular needle insertion, and proper disposal. The medication should be stored refrigerated but can be at room temperature for up to 24 hours before use.

PT-141 is administered via subcutaneous injection using the Vyleesi auto-injector device. Injection sites include the abdomen (avoiding 2 inches around navel) or anterior thigh. Site rotation is recommended to minimize injection site reactions. The auto-injector is single-use and pre-filled with 1.75 mg of bremelanotide. Patients should be trained on proper injection technique including site preparation with alcohol, perpendicular needle insertion, and proper disposal. The medication should be stored refrigerated but can be at room temperature for up to 24 hours before use.

Injection Protocol

• •Subcutaneous injection per protocol
• •Rotate injection sites
• •Consistent daily timing
• •Follow protocol guidelines

Monitoring Schedule

• •Regular progress monitoring
• •Health parameter monitoring
• •Laboratory monitoring
• •Safety monitoring