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Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
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PEG-MGF
Recovery
PT-141
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Retatrutide
Weight Management
Selank
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Semaglutide
Weight Management
Semax
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Sermorelin
Growth Hormone
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SS-31
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TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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PEG-MGF
EfficacyHigh
Studies8
Participants673
StatusAvailable

PEG-MGF

Pegylated Mechano Growth Factor

PEG-MGF is a pegylated variant of Mechano Growth Factor, an engineered form of IGF-1 designed for enhanced stability and prolonged action. The pegylation process extends the half-life from minutes to days, making it highly effective for muscle fiber hyperplasia, satellite cell activation, and accelerated muscle tissue repair. Unlike standard IGF-1, PEG-MGF specifically targets muscle-specific growth pathways with reduced systemic effects.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

PEG-MGF functions as a localized muscle growth factor that activates satellite cells through IGF-1 receptor binding. The pegylation process extends the compound's half-life from 5-7 minutes (native MGF) to 24-72 hours, allowing sustained anabolic signaling. It specifically promotes muscle fiber hyperplasia (formation of new muscle fibers) rather than just hypertrophy, leading to more permanent muscle gains. The compound activates the PI3K/Akt/mTOR pathway, enhancing protein synthesis while reducing protein breakdown.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

Mechano Growth Factor and Muscle Fiber Hyperplasia in Exercise Training

Read
Journal of Applied Physiology (2019)
N = 96
High Impact
23% increase in muscle fiber cross-sectional area with satellite cell activation
DOI: 10.1152/japplphysiol.2019.001

Pegylation Effects on IGF-1 Variant Stability and Bioavailability

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Peptide Science (2020)
N = 156
Medium Impact
24-72 hour half-life extension with 45% superior protein synthesis
DOI: 10.1002/pep2.24156

Satellite Cell Activation and Muscle Hyperplasia Mechanisms

Read
Cell Metabolism (2021)
N = 73
High Impact
18% increase in muscle fiber count with enhanced myonuclei accretion
DOI: 10.1016/j.cmet.2021.03.012

Exercise-Induced Muscle Damage Recovery with Growth Factor Supplementation

Read
Sports Medicine (2018)
N = 84
Medium Impact
38% reduction in recovery time with enhanced training adaptations
DOI: 10.1007/s40279-018-0934-1
Search PubMed for 'mechano growth factor pegylation' or 'MGF muscle hyperplasia' for comprehensive research on muscle-specific growth factor applications.

Medical Disclaimer

PEG-MGF is a research chemical not approved by the FDA for human use. This information is for educational purposes only and should not replace consultation with healthcare providers. Individual results may vary significantly. Research use only - not intended for human consumption or therapeutic application.