Eagle LogoPEPTIDE INITIATIVE

Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
Back to Home
MOTS-C
EfficacyHigh
Studies0
Participants0
StatusAvailable

MOTS-C

Mitochondrial Open Reading Frame of the 12S rRNA-c

MOTS-C is a 16-amino acid mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA. It plays a crucial role in regulating metabolic homeostasis, glucose metabolism, and insulin sensitivity. MOTS-C has shown promising therapeutic potential in aging, diabetes management, cardiovascular health, and physical performance enhancement. Currently in research phase with no clinical approval.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

MOTS-C functions as a mitochondrial-nuclear communication peptide that activates AMP-activated protein kinase (AMPK) signaling pathways. It modulates the folate/methionine cycle and enhances cellular stress resistance. MOTS-C interacts with nuclear genes to regulate metabolic homeostasis, particularly glucose metabolism and insulin sensitivity. The peptide promotes mitochondrial biogenesis, improves oxidative metabolism, and provides cytoprotection against age-related cellular damage.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

MOTS-c prevents pancreatic islet destruction in autoimmune diabetes

Read
Nature Metabolism (2022)
N = 0
High Impact
50% delay in diabetes onset in NOD mice with 40% reduction in inflammatory T-cell infiltration
DOI: 10.1038/s42255-022-00532-7

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline

Read
Nature Communications (2021)
N = 0
High Impact
Improved physical performance in mice across all age groups with MOTS-c supplementation
DOI: 10.1038/s41467-020-20790-0

Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging

Read
Journal of Translational Medicine (2023)
N = 225
High Impact
21% lower MOTS-c levels in humans aged 70-81 vs 18-30; negative correlation with HbA1c
DOI: 10.1186/s12967-023-03885-2

MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation

Read
BMC Medicine (2023)
N = 0
High Impact
Comprehensive review of MOTS-c therapeutic potential across multiple diseases
DOI: 10.1186/s12929-023-00892-0

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

Read
Free Radical Biology and Medicine (2016)
N = 0
High Impact
First identification of MOTS-c as metabolic regulator with AMPK pathway activation
DOI: 10.1016/j.freeradbiomed.2016.06.028
Search PubMed for 'MOTS-c mitochondrial peptide' for additional peer-reviewed research. Note that most studies are preclinical, with limited human data available.

Medical Disclaimer

MOTS-C is an experimental peptide not approved by the FDA for therapeutic use. It is banned by WADA for athletic competition. All information is for educational purposes only and should not constitute medical advice. Consult healthcare professionals before considering any peptide therapy. Long-term safety and efficacy in humans remain unknown.