MOTS-C
Mitochondrial Open Reading Frame of the 12S rRNA-c
MOTS-C is a 16-amino acid mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA. It plays a crucial role in regulating metabolic homeostasis, glucose metabolism, and insulin sensitivity. MOTS-C has shown promising therapeutic potential in aging, diabetes management, cardiovascular health, and physical performance enhancement. Currently in research phase with no clinical approval.
Complete Research Database
MOTS-c Autoimmune Diabetes Prevention
View StudyMOTS-c prevents pancreatic islet destruction in autoimmune diabetes
PRIMARY RESULTS
50% delay in diabetes onset with significant protection of pancreatic β-cells and reduced inflammatory infiltration
KEY FINDINGS
- •50% delay in autoimmune diabetes onset in NOD mice
- •40% reduction in inflammatory T-cell infiltration
- •Improved glucose tolerance and insulin secretion
- •AMPK pathway activation with mTORC1 inhibition
Age-Related Physical Performance Study
View StudyMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline
PRIMARY RESULTS
21% lower MOTS-c levels in elderly humans; significant physical performance improvement across all age groups in mice
KEY FINDINGS
- •21% decrease in MOTS-c levels in humans aged 70-81 vs 18-30
- •Improved physical performance in mice across age groups (2-23.5 months)
- •Enhanced mitochondrial function and energy metabolism
- •Exercise-induced MOTS-c expression demonstrated
Metabolic Effects and Mechanisms Review
View StudyMitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging
PRIMARY RESULTS
MOTS-c demonstrates multi-system benefits through AMPK activation, metabolic regulation, and stress resistance
KEY FINDINGS
- •AMPK pathway activation as primary mechanism
- •Folate/methionine cycle modulation effects
- •Cardiovascular protection through multiple pathways
- •Potential therapeutic applications across age-related diseases
Medical Disclaimer
MOTS-C is an experimental peptide not approved by the FDA for therapeutic use. It is banned by WADA for athletic competition. All information is for educational purposes only and should not constitute medical advice. Consult healthcare professionals before considering any peptide therapy. Long-term safety and efficacy in humans remain unknown.