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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
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Weight Management
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Growth Hormone
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Sleep & Recovery
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Anti-Aging
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Anti-Aging
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Growth Hormone
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Growth Hormone
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Kisspeptin
Hormone Support
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PT-141
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Cognitive
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Growth Hormone
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SS-31
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TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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Kisspeptin
EfficacyHigh
Studies8
Participants187
StatusAvailable

Kisspeptin

Kisspeptin-54 / Kisspeptin-10

Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates gonadotropin-releasing hormone (GnRH) secretion by binding to the GPR54/Kiss1R receptor, making it essential for reproductive function, puberty onset, and fertility. Originally discovered as a metastasis suppressor in certain cancers, kisspeptin has emerged as a promising therapeutic target for reproductive disorders including infertility, hypothalamic amenorrhea, and hypoactive sexual desire disorder.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

Kisspeptin exerts its effects by binding with high affinity to the G-protein coupled receptor GPR54 (also known as Kiss1R), which is predominantly expressed on GnRH neurons in the hypothalamus. Upon binding, it activates the Gq/11 signaling pathway, leading to increased intracellular calcium levels and phospholipase C activation. This cascade stimulates GnRH neurons to release GnRH into the hypothalamic-pituitary portal system, which subsequently binds to GnRH receptors on gonadotroph cells in the anterior pituitary. The result is pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate gonadal steroidogenesis and gametogenesis. The kisspeptin/Kiss1R system serves as the master regulator of reproductive function and is essential for pubertal development and maintenance of fertility.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization

Read
Journal of Clinical Investigation (2014)
N = 53
High Impact
23% clinical pregnancy rate with kisspeptin-54 triggering vs conventional hCG, with reduced OHSS risk
DOI: 10.1172/JCI75730

Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial

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JAMA Network Open (2022)
N = 32
High Impact
Kisspeptin modulated sexual and attraction brain processing with no adverse effects
DOI: 10.1001/jamanetworkopen.2022.36131

Kisspeptin treatment induces gonadotropic responses and rescues ovulation in women with polycystic ovary syndrome

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Journal of Clinical Endocrinology & Metabolism (2019)
N = 24
High Impact
Significant rise in LH and estradiol levels over 21 days with ovulation in subset of PCOS patients
DOI: 10.1210/clinem/dgz203

Safety Evaluation of KP-10 following once daily intravenous administration for 14 days in Dogs

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Frontiers in Pharmacology (2021)
N = 24
Medium Impact
No significant toxicity observed in 14-day dog study with normal organ histopathology
DOI: 10.3389/fphar.2021.627770

Kisspeptin and its Current Clinical Status-A Systematic Review

Read
Current Drug Metabolism (2024)
N = 150
High Impact
Systematic review of clinical trials confirming safety and efficacy across reproductive disorders
DOI: 10.2174/1389200224666221223120602
Search PubMed for 'kisspeptin reproductive endocrinology' or 'kisspeptin IVF fertility' for additional peer-reviewed research on reproductive applications.

Medical Disclaimer

Kisspeptin is in Phase 2 clinical trials for reproductive applications. This information is for educational purposes only and should not be construed as medical advice. Any clinical use should occur only under medical supervision in approved research or clinical settings.