Kisspeptin
Kisspeptin-54 / Kisspeptin-10
Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates gonadotropin-releasing hormone (GnRH) secretion by binding to the GPR54/Kiss1R receptor, making it essential for reproductive function, puberty onset, and fertility. Originally discovered as a metastasis suppressor in certain cancers, kisspeptin has emerged as a promising therapeutic target for reproductive disorders including infertility, hypothalamic amenorrhea, and hypoactive sexual desire disorder.
Complete Research Database
KISSPEPTIN-IVF Trial
View StudyKisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization
PRIMARY RESULTS
23% clinical pregnancy rate with kisspeptin-54 vs conventional hCG triggering, with significantly reduced OHSS risk
KEY FINDINGS
- •85-95% oocyte maturation rates depending on dose
- •Mean mature oocyte count 11.2 ± 4.7 per patient
- •LH surge comparable to natural mid-cycle peaks (43.2 ± 15.8 IU/L)
- •Zero cases of ovarian hyperstimulation syndrome
HYPOACTIVE Trial
View StudyEffects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder
PRIMARY RESULTS
Kisspeptin modulated sexual and attraction brain processing with no adverse effects during fMRI assessment
KEY FINDINGS
- •Enhanced brain activity in sexual processing regions
- •Improved response to attraction stimuli
- •No treatment-related adverse events
- •Potential therapeutic target for HSDD
PCOS Ovulation Study
View StudyKisspeptin treatment induces gonadotropic responses and rescues ovulation in women with PCOS
PRIMARY RESULTS
Significant rise in LH and estradiol levels with ovulation achieved in subset of participants
KEY FINDINGS
- •Restored gonadotropin responsiveness
- •Induced follicular growth in anovulatory women
- •Variable individual responses based on PCOS phenotype
- •Promising alternative to traditional ovulation induction
Medical Disclaimer
Kisspeptin is in Phase 2 clinical trials for reproductive applications. This information is for educational purposes only and should not be construed as medical advice. Any clinical use should occur only under medical supervision in approved research or clinical settings.