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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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Kisspeptin
EfficacyHigh
Studies8
Participants187
StatusAvailable

Kisspeptin

Kisspeptin-54 / Kisspeptin-10

Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates gonadotropin-releasing hormone (GnRH) secretion by binding to the GPR54/Kiss1R receptor, making it essential for reproductive function, puberty onset, and fertility. Originally discovered as a metastasis suppressor in certain cancers, kisspeptin has emerged as a promising therapeutic target for reproductive disorders including infertility, hypothalamic amenorrhea, and hypoactive sexual desire disorder.

Kisspeptin Mechanism of Action

The Complete Journey: From Injection to Results

Kisspeptin exerts its effects by binding with high affinity to the G-protein coupled receptor GPR54 (also known as Kiss1R), which is predominantly expressed on GnRH neurons in the hypothalamus. Upon binding, it activates the Gq/11 signaling pathway, leading to increased intracellular calcium levels and phospholipase C activation. This cascade stimulates GnRH neurons to release GnRH into the hypothalamic-pituitary portal system, which subsequently binds to GnRH receptors on gonadotroph cells in the anterior pituitary. The result is pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate gonadal steroidogenesis and gametogenesis. The kisspeptin/Kiss1R system serves as the master regulator of reproductive function and is essential for pubertal development and maintenance of fertility.

0-15 minutes

The Injection

You receive kisspeptin via subcutaneous injection. The peptide begins absorbing into your bloodstream and traveling to the hypothalamus.

BODY EFFECT
Initial absorption begins
WHAT YOU NOTICE
You might feel a slight pinch, then nothing - the peptide is starting its journey to your brain.
15-30 minutes

Receptor Binding & Activation

Kisspeptin binds to Kiss1R receptors on GnRH neurons in your hypothalamus, activating the Gq/11 signaling pathway and increasing intracellular calcium.

BODY EFFECT
Kiss1R receptors activating
WHAT YOU NOTICE
No noticeable effects yet - the peptide is binding to brain receptors and starting hormone cascades.
30-60 minutes

GnRH Release

Activated GnRH neurons release gonadotropin-releasing hormone into the hypothalamic-pituitary portal system, beginning the reproductive hormone cascade.

BODY EFFECT
GnRH neurons firing
WHAT YOU NOTICE
Still no obvious effects - hormone signals are traveling from brain to pituitary gland.
1-2 hours

LH & FSH Surge

Your pituitary gland releases luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in response to GnRH stimulation.

BODY EFFECT
Gonadotropin hormones surging
WHAT YOU NOTICE
You may begin to feel mild warmth or subtle energy changes as reproductive hormones increase.
2-12 hours

Peak Reproductive Response

LH and FSH reach peak levels (4-15x baseline), stimulating gonadal hormone production and triggering reproductive responses like ovulation or testosterone release.

BODY EFFECT
Maximum reproductive hormone activation
WHAT YOU NOTICE
Potential mild flushing, increased libido, or subtle mood changes as sex hormones respond.

How Kisspeptin Works at the Molecular Level

Scientific Mechanism

Kisspeptin exerts its effects by binding with high affinity to the G-protein coupled receptor GPR54 (also known as Kiss1R), which is predominantly expressed on GnRH neurons in the hypothalamus. Upon binding, it activates the Gq/11 signaling pathway, leading to increased intracellular calcium levels and phospholipase C activation. This cascade stimulates GnRH neurons to release GnRH into the hypothalamic-pituitary portal system, which subsequently binds to GnRH receptors on gonadotroph cells in the anterior pituitary. The result is pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate gonadal steroidogenesis and gametogenesis. The kisspeptin/Kiss1R system serves as the master regulator of reproductive function and is essential for pubertal development and maintenance of fertility.

Simple Explanation

Think of kisspeptin as the master key that unlocks your body's reproductive system. It works like a hormone messenger, binding to special receivers (Kiss1R receptors) in your brain's control center. When kisspeptin attaches to these receivers, it's like turning on a light switch that tells your brain to release GnRH hormone. This starts a chain reaction: your pituitary gland gets the message and releases two important hormones (LH and FSH) that tell your ovaries or testes to make sex hormones and prepare for reproduction. It's essentially the body's natural fertility coordinator, making sure all the reproductive pieces work together at the right time.

The Simple Truth: Why It Works So Well

Medical Disclaimer

Kisspeptin is in Phase 2 clinical trials for reproductive applications. This information is for educational purposes only and should not be construed as medical advice. Any clinical use should occur only under medical supervision in approved research or clinical settings.