HGH
Human Growth Hormone (Somatropin)
Human Growth Hormone (HGH), also known as somatropin when manufactured recombinantly, is a critical anabolic hormone that stimulates growth, cellular regeneration, and metabolism. FDA-approved for growth hormone deficiency in children and adults, Turner syndrome, and other growth disorders. HGH promotes lean muscle mass, reduces body fat, improves bone density, and enhances overall quality of life through its primary mediator, insulin-like growth factor-1 (IGF-1).
Complete Research Database
Dual Receptor Mechanism (GIP/GLP-1)
GLP-1 Receptor Pathway
- •Increases insulin secretion (glucose-dependent)
- •Suppresses glucagon release
- •Slows gastric emptying
- •Enhances satiety in hypothalamus
- •Preserves beta-cell function
GIP Receptor Pathway
- •Enhances insulin secretion (stronger than GLP-1)
- •Promotes fat oxidation
- •Improves insulin sensitivity in muscle
- •Reduces hepatic glucose production
- •Modulates adipose tissue metabolism
Why Dual Agonism is Superior
Human Growth Hormone exerts its effects by binding to growth hormone receptors (GHR) throughout the body, particularly in liver, muscle, bone, and adipose tissue. This binding activates the JAK2-STAT5 signaling pathway, leading to increased transcription of IGF-1 and other growth-promoting genes. IGF-1, produced primarily in the liver, mediates most of HGH's anabolic effects through IGF-1 receptors, promoting protein synthesis, cellular proliferation, and tissue growth while enhancing lipolysis and glucose metabolism.
Pharmacokinetic Profile
Top 10 High-Quality Research Articles
Safety and Efficacy of Growth Hormone Treatment in Adults: NCGS Analysis
ReadAdult Growth Hormone Deficiency: Diagnosis and Treatment Guidelines
ReadLong-term Safety of Growth Hormone Replacement: KIMS Database
ReadGrowth Hormone and Aging: A Systematic Review
ReadExercise Capacity and Growth Hormone Replacement Therapy
ReadMedical Disclaimer
Human Growth Hormone (HGH/Somatropin) is FDA-approved for growth hormone deficiency and specific medical conditions. This information is for educational purposes and should not replace consultation with qualified healthcare providers. HGH requires prescription and medical supervision for all therapeutic uses. Individual results may vary based on baseline hormone levels and clinical status.