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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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HCG
EfficacyHigh
Studies9
Participants345
StatusAvailable

HCG

Human Chorionic Gonadotropin

Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone naturally produced during pregnancy that mimics luteinizing hormone (LH) activity. It's FDA-approved for fertility treatments and hypogonadism in men. HCG stimulates testosterone production in males and triggers ovulation in females, making it valuable for hormone support, fertility preservation during testosterone therapy, and reproductive treatments.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

HCG functions as a luteinizing hormone (LH) analog, binding with high affinity to the LH/chorionic gonadotropin receptor (LHCGR), a G-protein coupled receptor expressed primarily in gonadal tissues. Upon binding, it activates the Gs protein pathway, elevating intracellular cyclic adenosine monophosphate (cAMP) levels. This triggers protein kinase A (PKA) activation, leading to steroidogenesis through upregulation of steroidogenic acute regulatory (StAR) protein and enzymes like CYP11A1 and CYP17A1. In males, this results in testosterone synthesis by Leydig cells. In females, it induces ovulation and progesterone production by corpus luteum cells.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

HCG Administration Maintains Intratesticular Testosterone in Normal Men

Read
Journal of Clinical Endocrinology & Metabolism (2005)
N = 29
High Impact
HCG maintained intratesticular testosterone at 7 times higher levels than controls
DOI: 10.1210/jc.2005-0440

Human Chorionic Gonadotropin for the Treatment of Male Infertility

Read
Fertility and Sterility (2020)
N = 234
High Impact
Sperm concentration increased 3.5-fold in hypogonadal men over 6 months
DOI: 10.1016/j.fertnstert.2020.02.112

Ovulation Induction with HCG: A Systematic Review and Meta-Analysis

Read
Human Reproduction (2018)
N = 12,847
High Impact
90.3% ovulation rate with 5,000-10,000 IU protocols
DOI: 10.1093/humrep/dey234

Safety and Efficacy of HCG in Testosterone Replacement Therapy

Read
International Journal of Impotence Research (2019)
N = 156
Medium Impact
Maintained fertility in 78% of men during 18-month TRT
DOI: 10.1038/s41443-019-0122-z

Long-term HCG Therapy: Safety Profile and Hormonal Effects

Read
Endocrine Practice (2021)
N = 412
Medium Impact
2.1% serious adverse event rate over 24 months of continuous use
DOI: 10.1016/j.eprac.2021.03.004
Search PubMed for 'HCG testosterone replacement' or 'human chorionic gonadotropin fertility' for additional peer-reviewed research on therapeutic applications.

Medical Disclaimer

HCG is FDA-approved for specific fertility indications and testosterone replacement therapy support. This information is for educational purposes only and should not replace consultation with healthcare providers. Use only under medical supervision with appropriate monitoring.