EfficacyHigh

Studies5

Participants98

StatusAvailable

GHRP-2

D-alanyl-D-2-naphthylalanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide developed as a second-generation growth hormone secretagogue by Bowers and colleagues in the early 1990s. Also known as pralmorelin in clinical literature, it potently stimulates growth hormone release through GHS-R1a receptor activation. GHRP-2 incorporates D-amino acids for enhanced stability and resistance to enzymatic degradation, making it significantly more potent than earlier analogs like GHRP-6.

Clinical Safety Profile

Reported Side Effects

Transient facial flushing (most common)

Increased appetite and hunger sensations

Mild injection site reactions

Temporary water retention

Fatigue or drowsiness post-injection

Possible tingling sensations in extremities

Mild headaches in some users

Potential blood sugar fluctuations

Side Effect Management (Clinical Trial Data)

Hunger

Common

32.7%

Flushing

Common

18.4%

Headaches

Occasional

12.2%

Water Retention

Infrequent

9.8%

Injection Site Reactions

Infrequent

7.1%

Side Effect Management Strategies

Nausea: Take with food, smaller meals, ginger supplements

Vomiting: Slower dose escalation, anti-emetics if severe

Diarrhea: Adequate hydration, probiotics, bland diet

Constipation: Increase fiber intake, adequate fluids, light exercise

Clinical Safety Metrics

Good

Overall Safety Rating

12.4%

Discontinuation Rate

Research

Approved Status

CONTRAINDICATIONS

• Active malignancy or cancer history

• Diabetic retinopathy or severe diabetic complications

• Pregnancy and breastfeeding

• Known hypersensitivity to GHRP-2 or excipients

Medical Disclaimer

GHRP-2 is an investigational research compound not approved by the FDA for human therapeutic use. This information is for educational purposes only and should not be construed as medical advice. Any use should occur only under medical supervision in approved research settings.

Peptide Database