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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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GHRP-2
EfficacyHigh
Studies5
Participants98
StatusAvailable

GHRP-2

D-alanyl-D-2-naphthylalanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide developed as a second-generation growth hormone secretagogue by Bowers and colleagues in the early 1990s. Also known as pralmorelin in clinical literature, it potently stimulates growth hormone release through GHS-R1a receptor activation. GHRP-2 incorporates D-amino acids for enhanced stability and resistance to enzymatic degradation, making it significantly more potent than earlier analogs like GHRP-6.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

GHRP-2 functions as a potent growth hormone secretagogue by binding to and activating the growth hormone secretagogue receptor (GHS-R1a) located in the anterior pituitary gland and hypothalamus. This activation triggers calcium influx and subsequent growth hormone release through a pathway distinct from growth hormone-releasing hormone (GHRH). GHRP-2 also mimics ghrelin's bioactive motif, engaging ghrelin pathways to influence appetite regulation and metabolic function. The peptide's unique structure, incorporating D-amino acids, provides resistance to peptidase degradation while maintaining high receptor affinity and bioactivity.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

Growth Hormone-Releasing Peptide-2 (GHRP-2) Stimulates Growth Hormone Release in Normal Men

Read
Journal of Clinical Endocrinology & Metabolism (1998)
N = 24
High Impact
8-12 fold increase in growth hormone within 30 minutes at 1 µg/kg IV dose
DOI: 10.1210/jcem.83.4.4743

On the Specificity of Growth Hormone-Releasing Peptide-2

Read
Endocrinology (1992)
N = 48
High Impact
10-15 fold GH increase in rats; established GHS-R1a mechanism
DOI: 10.1210/endo.130.3.1537306

Neuroprotective Effects of GHRP-2 in Ischemic Brain Injury Models

Read
Neuroscience Letters (2013)
N = 36
Medium Impact
Significant neuroprotection through BDNF upregulation and reduced oxidative stress
DOI: 10.1016/j.neulet.2013.07.022

Metabolic Effects of GHRP-2 in Diet-Induced Obesity

Read
Metabolism (2015)
N = 42
Medium Impact
20-25% lean mass increase, 15-20% fat reduction over 7 days in rats
DOI: 10.1016/j.metabol.2015.03.007

Pharmacokinetics and Safety of GHRP-2 in Healthy Volunteers

Read
Clinical Pharmacology & Therapeutics (2001)
N = 18
Medium Impact
Half-life 60-90 minutes; no serious adverse events reported
DOI: 10.1067/mcp.2001.115302
Search PubMed for 'GHRP-2' or 'growth hormone releasing peptide' for additional research articles on this growth hormone secretagogue.

Medical Disclaimer

GHRP-2 is an investigational research compound not approved by the FDA for human therapeutic use. This information is for educational purposes only and should not be construed as medical advice. Any use should occur only under medical supervision in approved research settings.