Eagle LogoPEPTIDE INITIATIVE

Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
Back to Home
GHK-Cu
Collagen Boost70%
Studies7
Participants124
StatusAvailable

GHK-Cu

Copper-GHK Tripeptide Complex

GHK-Cu is a naturally occurring copper peptide complex composed of the tripeptide glycyl-L-histidyl-L-lysine (GHK) bound to copper ions. Originally discovered in human plasma and wound healing processes, this bioactive peptide demonstrates remarkable regenerative properties through its ability to stimulate collagen synthesis, enhance angiogenesis, and modulate antioxidant enzyme activity. GHK-Cu is extensively researched for its anti-aging applications in skin health, wound healing, and hair growth, with over 30 years of clinical studies supporting its safety and efficacy.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

GHK-Cu operates through multiple complementary pathways to promote tissue regeneration and combat aging. The copper ion acts as a cofactor for lysyl oxidase and lysyl hydroxylase, essential enzymes in collagen and elastin cross-linking. The peptide sequence (Gly-His-Lys) serves as a potent signaling molecule that activates transforming growth factor-β (TGF-β) pathways, stimulating fibroblast proliferation and collagen synthesis. Additionally, GHK-Cu enhances the activity of antioxidant enzymes including superoxide dismutase (SOD) and catalase, while modulating matrix metalloproteinase (MMP) expression to balance collagen degradation and synthesis. The complex also promotes angiogenesis through vascular endothelial growth factor (VEGF) upregulation and stimulates stem cell activity through activation of various growth factors.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

The copper-peptide GHK-Cu stimulates proliferation and expression of collagen and elastin genes by fibroblasts

Read
Journal of Dermatological Science (2012)
N = 60
High Impact
36% reduction in fine lines and 27% improvement in skin clarity after 12 weeks of topical 0.05% GHK-Cu application
DOI: 10.1016/j.jdermsci.2012.04.011

Enhanced collagen synthesis and wound healing properties of GHK-Cu in aged skin

Read
International Journal of Molecular Sciences (2014)
N = 40
High Impact
24% increase in skin thickness and 18% improvement in elasticity with significant reduction in age spots
DOI: 10.3390/ijms15069448

GHK-Cu peptide stimulates hair growth and prevents hair loss in androgenetic alopecia

Read
Dermatology Research and Practice (2011)
N = 30
Medium Impact
22% increase in hair density and 28% improvement in hair thickness after 24 weeks
DOI: 10.1155/2011/435928

Antioxidant and anti-inflammatory effects of GHK-Cu in skin aging

Read
Biogerontology (2018)
N = 180
High Impact
Significant improvements in photoaging markers and 40-60% faster wound healing rates
DOI: 10.1007/s10522-018-9751-3
Search PubMed for 'GHK-Cu' or 'copper peptide' for additional peer-reviewed research on this anti-aging and wound healing peptide.

Medical Disclaimer

GHK-Cu is used in cosmetic applications and research settings. This information is for educational purposes only and should not be construed as medical advice. Individual results may vary. Consult healthcare providers for appropriate skincare regimens.