GHK-Cu
Copper-GHK Tripeptide Complex
GHK-Cu is a naturally occurring copper peptide complex composed of the tripeptide glycyl-L-histidyl-L-lysine (GHK) bound to copper ions. Originally discovered in human plasma and wound healing processes, this bioactive peptide demonstrates remarkable regenerative properties through its ability to stimulate collagen synthesis, enhance angiogenesis, and modulate antioxidant enzyme activity. GHK-Cu is extensively researched for its anti-aging applications in skin health, wound healing, and hair growth, with over 30 years of clinical studies supporting its safety and efficacy.
Complete Dosing Guide
Quick Reference
Administration Method
Topical cream/serum application or subcutaneous injection
Step-by-Step Dosing Protocol
Dosing Guidelines
Topical applications typically use 0.05-2% concentrations in cosmetic formulations, applied once or twice daily. For research subcutaneous administration, doses range from 1-5 mg diluted in saline, administered 2-3 times weekly. Wound healing protocols often use higher concentrations (2-5%) applied directly to affected areas under medical supervision. Hair growth treatments typically employ 1-2% concentrations in serums applied to scalp daily. Clinical studies have used various protocols: 0.05% daily for anti-aging (Arul et al.), 1% twice daily for photoaging, and 2% for wound healing applications.
For everyday anti-aging skincare, use products with 0.05-2% GHK-Cu concentration once or twice daily - think of it like your daily moisturizer routine. For serious skin repair or hair growth, you might use 1-2% concentration daily. If you're dealing with wounds or injuries under medical care, stronger 2-5% concentrations can be applied directly. Research injections use tiny amounts (1-5 mg) a few times per week - but that's only for scientific studies, not home use!
Mixing & Injection
Topical application is the most common method, with GHK-Cu incorporated into serums, creams, and specialized delivery systems like liposomes or nanoparticles for enhanced penetration. Apply to clean skin, allowing full absorption before additional products. For research purposes, subcutaneous injection uses sterile saline dilution, administered with insulin syringes at depths of 4-6mm. Mesotherapy techniques employ multiple shallow injections across treatment areas. Iontophoresis and electroporation can enhance dermal delivery. Storage requires refrigeration and protection from light to maintain copper complex stability.
Topical application is the most common method, with GHK-Cu incorporated into serums, creams, and specialized delivery systems like liposomes or nanoparticles for enhanced penetration. Apply to clean skin, allowing full absorption before additional products. For research purposes, subcutaneous injection uses sterile saline dilution, administered with insulin syringes at depths of 4-6mm. Mesotherapy techniques employ multiple shallow injections across treatment areas. Iontophoresis and electroporation can enhance dermal delivery. Storage requires refrigeration and protection from light to maintain copper complex stability.
Clinical Administration Guidelines
Injection Protocol
- •Topical application or subcutaneous injection
- •Apply to different facial areas or rotate injection sites
- •Evening application as part of skincare routine
- •Apply to clean skin for topical use
Monitoring Schedule
- •Daily skin quality and texture assessment
- •Monthly dermatological professional assessment
- •Quarterly comprehensive health panels
- •STOP if severe skin irritation or allergic reactions
Dosage Calculator
Medical Disclaimer
GHK-Cu is used in cosmetic applications and research settings. This information is for educational purposes only and should not be construed as medical advice. Individual results may vary. Consult healthcare providers for appropriate skincare regimens.