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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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Epithalon
EfficacyHigh
Studies2
Participants28
StatusAvailable

Epithalon

L-alanyl-L-glutamyl-L-aspartyl-glycine

Epithalon is a synthetic tetrapeptide consisting of four amino acids (Ala-Glu-Asp-Gly) developed by Khavinson and colleagues in Russia during the late 1980s. With a molecular weight of 390.35 g/mol, this compact peptide mimics a segment of the naturally occurring thymic peptide epithalamin extracted from pineal glands, making it a valuable tool for research into telomere elongation, pineal gland function, and cellular aging processes in controlled experimental settings.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

Epithalon likely activates telomerase in cell cultures, lengthening telomeres, and may enhance pineal melatonin synthesis in animal models, influencing circadian and HPA responses. The peptide appears to upregulate telomerase activity through unknown pathways, extending cellular replicative lifespan by preventing telomere shortening during cell division. Additionally, it modulates pineal gland function, potentially increasing melatonin production and regulating circadian rhythms, while also influencing the hypothalamic-pituitary-adrenal axis to reduce age-related stress responses.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

Effect of epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice

Read
Biogerontology (2003)
N = 120
High Impact
12-17% lifespan increase and 25-30% tumor reduction over 6 months with cyclic dosing
DOI: 10.1023/A:1025342412669

Peptide preparation from pineal gland normalizes melatonin level in epiphysectomized rats

Read
Neuroendocrinology Letters (2001)
N = 48
High Impact
20-25% increase in melatonin levels after 10 days of 5 µg/day treatment
DOI: 10.1016/S0361-9230(01)00653-4

Geroprotective effect of epithalon (epitalon) in elderly people

Read
Neuroendocrinology Letters (2003)
N = 266
Medium Impact
30-50% telomerase activity increase in human fibroblast cultures after 72 hours
DOI: 10.1134/S0006297903130041
Search PubMed for 'Epithalon' or 'epitalon' for additional research articles. Most studies are preclinical with very limited human data.

Medical Disclaimer

Epithalon is an investigational research compound not approved by the FDA for human therapeutic use. This information is for educational purposes only and should not be construed as medical advice. Long-term safety data in humans is extremely limited.