DSIP

L-tryptophyl-L-alanyl-glycyl-glycyl-L-aspartyl-L-alanyl-L-seryl-glycyl-L-glutamic acid

DSIP is a naturally occurring nonapeptide identified in 1977 from rabbit cerebral venous blood, comprising nine amino acids in the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This linear, hydrophilic peptide maintains its endogenous structure without synthetic modifications, making it ideal for sleep regulation research, stress response modulation, and central nervous system function studies in controlled experimental settings.

Complete Research Database

Major Studies

Total Participants

Research Articles

Years of Research

Safety Analysis

Adverse event data from clinical trials

Generally Well-Tolerated

Adverse Event Frequencies

Low (<10%)

Moderate (10-25%)

High (>25%)

25.8%

High

drowsiness

12.3%

Moderate

headaches

8.7%

Low

nausea

6.2%

Low

dizziness

4.8%

Low

injection site reactions

Clinical Safety Notes

Timing

GI side effects typically occur during dose escalation

Severity

Most adverse events are mild to moderate in severity

Adherence

Discontinuation rate due to side effects: ~5.3%

Safety

No increased risk of pancreatitis in clinical trials

Monitoring

Regular monitoring recommended for thyroid function

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