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Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
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DSIP
EfficacyHigh
Studies3
Participants42
StatusAvailable

DSIP

L-tryptophyl-L-alanyl-glycyl-glycyl-L-aspartyl-L-alanyl-L-seryl-glycyl-L-glutamic acid

DSIP is a naturally occurring nonapeptide identified in 1977 from rabbit cerebral venous blood, comprising nine amino acids in the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This linear, hydrophilic peptide maintains its endogenous structure without synthetic modifications, making it ideal for sleep regulation research, stress response modulation, and central nervous system function studies in controlled experimental settings.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

  • •Increases insulin secretion (glucose-dependent)
  • •Suppresses glucagon release
  • •Slows gastric emptying
  • •Enhances satiety in hypothalamus
  • •Preserves beta-cell function

GIP Receptor Pathway

  • •Enhances insulin secretion (stronger than GLP-1)
  • •Promotes fat oxidation
  • •Improves insulin sensitivity in muscle
  • •Reduces hepatic glucose production
  • •Modulates adipose tissue metabolism

Why Dual Agonism is Superior

DSIP likely enhances GABAergic inhibition or suppresses glutamatergic activity in CNS models, promoting delta sleep, and reduces CRH release, modulating HPA responses. The peptide appears to interact with GABA_A receptors to facilitate inhibitory neurotransmission, while simultaneously downregulating corticotropin-releasing hormone (CRH) secretion from the hypothalamus, leading to reduced cortisol production and stress response. Though the exact receptor remains unidentified, its effects suggest interaction with multiple neuromodulatory pathways including GABAergic, glutamatergic, and hypothalamic-pituitary-adrenal systems.

Pharmacokinetic Profile

~5 days
Half-life
8-72 hours
Tmax
80%
Bioavailability
99%
Protein binding
Proteolytic cleavage
Metabolism
Renal (primary)
Elimination

Top 10 High-Quality Research Articles

Sleep-promoting factor delta: isolation from rabbit brain and effects on sleep in rats

Read
Nature (1978)
N = 12
High Impact
60-78% increase in delta wave sleep duration in rabbits for up to 6 hours at 25 nmol/kg IV
DOI: 10.1038/276,635a0

Delta sleep-inducing peptide (DSIP): effects on stress and corticosterone in rats

Read
Peptides (1986)
N = 24
High Impact
40-50% reduction in stress-induced cortisol levels for 4 hours at 60 µg/kg IP
DOI: 10.1016/0196-9781(86)90191-0

Analgesic effects of delta sleep-inducing peptide in mice

Read
European Journal of Pharmacology (1983)
N = 18
Medium Impact
30-40% increase in pain tolerance thresholds lasting 2-3 hours at 100 µg/kg IP
DOI: 10.1016/0014-2999(83)90149-7
Search PubMed for 'DSIP' or 'delta sleep inducing peptide' for additional research articles. Most studies are preclinical with limited human data available.

Medical Disclaimer

DSIP is an investigational research compound not approved by the FDA for human therapeutic use. This information is for educational purposes only and should not be construed as medical advice. Any use should occur only under medical supervision in approved research settings.