BPC-157

Body Protection Compound-157

BPC-157 is a pentadecapeptide composed of 15 amino acids derived from body protective compound found in human gastric juice. This synthetic peptide demonstrates remarkable healing and regenerative properties across multiple tissue types including muscle, tendon, ligament, bone, and gastrointestinal tract. While primarily research-stage, BPC-157 has shown consistent protective effects in over 100 preclinical studies, making it one of the most promising healing peptides under investigation.

Complete Research Database

Dual Receptor Mechanism (GIP/GLP-1)

GLP-1 Receptor Pathway

•Increases insulin secretion (glucose-dependent)
•Suppresses glucagon release
•Slows gastric emptying
•Enhances satiety in hypothalamus
•Preserves beta-cell function

GIP Receptor Pathway

•Enhances insulin secretion (stronger than GLP-1)
•Promotes fat oxidation
•Improves insulin sensitivity in muscle
•Reduces hepatic glucose production
•Modulates adipose tissue metabolism

Why Dual Agonism is Superior

BPC-157 exerts its healing effects through multiple molecular pathways including activation of the VEGFR2-Akt-eNOS signaling pathway, promotion of angiogenesis via VEGF upregulation, modulation of growth factor expression (PDGF-BB, EGF, FGF), and interaction with the nitric oxide system. It stabilizes gastric pentadecapeptide BPC 157 by counteracting leaky gut syndrome, promotes collagen synthesis, and demonstrates cytoprotective effects through antioxidant mechanisms and mitochondrial protection.

Pharmacokinetic Profile

~5 days

Half-life

8-72 hours

Tmax

80%

Bioavailability

99%

Protein binding

Proteolytic cleavage

Metabolism

Renal (primary)

Elimination

Peptide Database