
Adipotide
Prohibitin-targeting peptide 1 (Prohibitin-TP01)
Adipotide is a revolutionary experimental vascular-targeting peptidomimetic designed to induce selective apoptosis in blood vessels supplying white adipose tissue. Also known as Prohibitin-TP01, FTPP (Fat-Targeted Proapoptotic Peptide), or TP-1, it represents a completely novel approach to weight management through direct fat cell elimination rather than appetite suppression. While clinical development was discontinued in 2019 due to nephrotoxicity concerns, preclinical studies demonstrated remarkable efficacy with up to 30% weight reduction in rodent models and 11% weight loss in primate studies over just 28 days.
Complete Dosing Guide
Quick Reference
Administration Method
Subcutaneous injection once daily with site rotation, 28-day cycles
Step-by-Step Dosing Protocol
Dosing Guidelines
Research protocols established 0.43 mg/kg daily subcutaneous injection as the optimal efficacious dose based on primate studies, administered for 28-day treatment cycles followed by mandatory 28-56 day recovery periods. For a 70kg human, this translates to approximately 30mg daily. Alternative investigational schedules suggest 0.3-0.5 mg/kg for weeks 1-2 to assess tolerance, escalating to 0.43 mg/kg for weeks 3-4 if kidney function remains stable. Injection sites must be rotated daily between abdomen, thigh, and upper arm to prevent lipodystrophy. Critical monitoring includes twice-weekly serum creatinine, BUN, urinalysis, and comprehensive metabolic panels due to nephrotoxicity risk. Treatment should be discontinued immediately if creatinine rises >50% above baseline.
Since Adipotide was never approved for humans, dosing is based entirely on animal research. The standard monkey dose was about 0.4mg per kilogram of body weight daily - so a 150-pound person would theoretically use about 30mg per day. You inject it under the skin once daily for exactly 28 days, then take at least 28 days completely off to let your kidneys recover. You must change injection spots every day to avoid skin problems. Because of serious kidney risks, you'd need blood tests twice a week to check kidney function, and stop immediately if your kidney numbers get worse. This isn't like other peptides where you can adjust doses - the kidney toxicity makes it an all-or-nothing proposition.
Mixing & Injection
Subcutaneous injection using insulin syringes or pen devices, administered once daily at consistent timing. Reconstitute lyophilized powder with bacteriostatic water to achieve appropriate concentration based on body weight calculations. Inject into subcutaneous tissue at 45-90 degree angle using proper sterile technique. Mandatory site rotation between abdomen (avoiding 2-inch radius around navel), anterior thigh, and posterior upper arm to prevent injection site complications. Administer at same time daily, preferably morning to monitor for acute adverse reactions during active hours. Unlike other peptides, Adipotide requires strict adherence to 28-day treatment windows with mandatory recovery periods. Concurrent hydration monitoring and nephrotoxicity assessment through regular laboratory evaluation is essential and non-optional.
Subcutaneous injection using insulin syringes or pen devices, administered once daily at consistent timing. Reconstitute lyophilized powder with bacteriostatic water to achieve appropriate concentration based on body weight calculations. Inject into subcutaneous tissue at 45-90 degree angle using proper sterile technique. Mandatory site rotation between abdomen (avoiding 2-inch radius around navel), anterior thigh, and posterior upper arm to prevent injection site complications. Administer at same time daily, preferably morning to monitor for acute adverse reactions during active hours. Unlike other peptides, Adipotide requires strict adherence to 28-day treatment windows with mandatory recovery periods. Concurrent hydration monitoring and nephrotoxicity assessment through regular laboratory evaluation is essential and non-optional.
Clinical Administration Guidelines
Injection Protocol
- •Subcutaneous injection DAILY for 28 days
- •MANDATORY daily site rotation (abdomen, thigh, arm)
- •Same time DAILY (preferably morning for monitoring)
- •CRITICAL: Take with adequate hydration
Monitoring Schedule
- •CRITICAL: Twice-weekly serum creatinine & BUN
- •CRITICAL: Twice-weekly urinalysis for protein
- •CRITICAL: Weekly comprehensive metabolic panel
- •STOP IMMEDIATELY if creatinine >50% above baseline
Dosage Calculator
Medical Disclaimer
CRITICAL WARNING: Adipotide clinical development was permanently discontinued due to unacceptable nephrotoxicity. All human trials were terminated early. This information is for educational purposes only. Adipotide is NOT approved for any human use and carries severe kidney damage risks. Consult healthcare providers for approved weight management alternatives.