Eagle LogoPEPTIDE INITIATIVE

Peptide Database

Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 31
Back to Home
Adipotide
Max Weight Loss14.7%
Studies2
Participants48
StatusLimited

Adipotide

Prohibitin-targeting peptide 1 (Prohibitin-TP01)

Adipotide is a revolutionary experimental vascular-targeting peptidomimetic designed to induce selective apoptosis in blood vessels supplying white adipose tissue. Also known as Prohibitin-TP01, FTPP (Fat-Targeted Proapoptotic Peptide), or TP-1, it represents a completely novel approach to weight management through direct fat cell elimination rather than appetite suppression. While clinical development was discontinued in 2019 due to nephrotoxicity concerns, preclinical studies demonstrated remarkable efficacy with up to 30% weight reduction in rodent models and 11% weight loss in primate studies over just 28 days.

Complete Dosing Guide

Quick Reference

0.43
Typical Dose
Daily
Frequency
Approximately
Half-Life
SubQ
Route

Administration Method

Subcutaneous injection once daily with site rotation, 28-day cycles

Step-by-Step Dosing Protocol

Initial
0.43 mg/kg daily (research protocol from primate studies)
Getting started
Follow gradual escalation approach
Maintenance
Optimized dose
Sustained benefits
Continue at effective dose
Cycling
Break period
Recovery
Take breaks to maintain effectiveness

Dosing Guidelines

Research Protocol

Research protocols established 0.43 mg/kg daily subcutaneous injection as the optimal efficacious dose based on primate studies, administered for 28-day treatment cycles followed by mandatory 28-56 day recovery periods. For a 70kg human, this translates to approximately 30mg daily. Alternative investigational schedules suggest 0.3-0.5 mg/kg for weeks 1-2 to assess tolerance, escalating to 0.43 mg/kg for weeks 3-4 if kidney function remains stable. Injection sites must be rotated daily between abdomen, thigh, and upper arm to prevent lipodystrophy. Critical monitoring includes twice-weekly serum creatinine, BUN, urinalysis, and comprehensive metabolic panels due to nephrotoxicity risk. Treatment should be discontinued immediately if creatinine rises >50% above baseline.

Simple Explanation

Since Adipotide was never approved for humans, dosing is based entirely on animal research. The standard monkey dose was about 0.4mg per kilogram of body weight daily - so a 150-pound person would theoretically use about 30mg per day. You inject it under the skin once daily for exactly 28 days, then take at least 28 days completely off to let your kidneys recover. You must change injection spots every day to avoid skin problems. Because of serious kidney risks, you'd need blood tests twice a week to check kidney function, and stop immediately if your kidney numbers get worse. This isn't like other peptides where you can adjust doses - the kidney toxicity makes it an all-or-nothing proposition.

Mixing & Injection

Technical Instructions

Subcutaneous injection using insulin syringes or pen devices, administered once daily at consistent timing. Reconstitute lyophilized powder with bacteriostatic water to achieve appropriate concentration based on body weight calculations. Inject into subcutaneous tissue at 45-90 degree angle using proper sterile technique. Mandatory site rotation between abdomen (avoiding 2-inch radius around navel), anterior thigh, and posterior upper arm to prevent injection site complications. Administer at same time daily, preferably morning to monitor for acute adverse reactions during active hours. Unlike other peptides, Adipotide requires strict adherence to 28-day treatment windows with mandatory recovery periods. Concurrent hydration monitoring and nephrotoxicity assessment through regular laboratory evaluation is essential and non-optional.

Step-by-Step Guide

Subcutaneous injection using insulin syringes or pen devices, administered once daily at consistent timing. Reconstitute lyophilized powder with bacteriostatic water to achieve appropriate concentration based on body weight calculations. Inject into subcutaneous tissue at 45-90 degree angle using proper sterile technique. Mandatory site rotation between abdomen (avoiding 2-inch radius around navel), anterior thigh, and posterior upper arm to prevent injection site complications. Administer at same time daily, preferably morning to monitor for acute adverse reactions during active hours. Unlike other peptides, Adipotide requires strict adherence to 28-day treatment windows with mandatory recovery periods. Concurrent hydration monitoring and nephrotoxicity assessment through regular laboratory evaluation is essential and non-optional.

Clinical Administration Guidelines

Injection Protocol

  • Subcutaneous injection DAILY for 28 days
  • MANDATORY daily site rotation (abdomen, thigh, arm)
  • Same time DAILY (preferably morning for monitoring)
  • CRITICAL: Take with adequate hydration

Monitoring Schedule

  • CRITICAL: Twice-weekly serum creatinine & BUN
  • CRITICAL: Twice-weekly urinalysis for protein
  • CRITICAL: Weekly comprehensive metabolic panel
  • STOP IMMEDIATELY if creatinine >50% above baseline

Dosage Calculator

Loading Calculator...

Medical Disclaimer

CRITICAL WARNING: Adipotide clinical development was permanently discontinued due to unacceptable nephrotoxicity. All human trials were terminated early. This information is for educational purposes only. Adipotide is NOT approved for any human use and carries severe kidney damage risks. Consult healthcare providers for approved weight management alternatives.