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NAD+
EfficacyHigh
Studies8
Participants572
StatusAvailable

NAD+

Nicotinamide Adenine Dinucleotide

NAD+ is a vital coenzyme present in every cell that plays crucial roles in energy metabolism, DNA repair, and cellular aging processes. As NAD+ levels naturally decline with age (by ~50% by age 50), supplementation through IV therapy or injections aims to restore cellular energy production, activate longevity pathways through sirtuin proteins, and support mitochondrial health. Research demonstrates significant improvements in cognitive function, physical performance, and biomarkers of aging.

Complete Dosing Guide

Quick Reference

250-1000
Typical Dose
Variable
Frequency
30
Half-Life
SubQ
Route

Administration Method

IV infusion (2-4 hours) or subcutaneous injection

Step-by-Step Dosing Protocol

Initial
250-1000 mg per session (IV or injection)
Getting started
Follow gradual escalation approach
Maintenance
Optimized dose
Sustained benefits
Continue at effective dose
Cycling
Break period
Recovery
Take breaks to maintain effectiveness

Dosing Guidelines

Research Protocol

NAD+ dosing varies significantly based on administration route and therapeutic goals. For IV infusions, initial doses start at 250mg administered over 2-3 hours to assess tolerance, with gradual escalation to 500-750mg per session. Maintenance protocols typically use 500mg 2-3 times weekly. Higher doses (1000mg+) are reserved for intensive protocols under medical supervision. Subcutaneous injection protocols use 100-200mg daily or every other day. Treatment frequency depends on individual response and goals: acute interventions may use daily dosing for 1-2 weeks, while maintenance protocols use 2-3 sessions weekly. Oral NAD+ precursors (NMN, NR) are often used between IV sessions at doses of 250-500mg daily. Close monitoring of energy levels, sleep quality, and tolerance guides dose optimization.

Simple Explanation

NAD+ therapy typically follows a 'start low and go slow' approach because everyone responds differently. Most people begin with a smaller dose (250mg) given through an IV over 2-3 hours to see how they react. If that goes well, the dose is gradually increased to 500-750mg per session. Think of it like starting a new exercise program - you don't run a marathon on day one. Most people end up with 2-3 IV sessions per week for optimal benefits. Some people prefer daily smaller injections instead of longer IV sessions. The key is finding your personal sweet spot where you get the energy and cognitive benefits without feeling overstimulated or experiencing side effects. Many people also take oral NAD+ boosters on non-treatment days to maintain steady levels.

Mixing & Injection

Technical Instructions

IV infusion remains the gold standard for NAD+ delivery, using slow infusion rates (typically 2-4 hours) to minimize side effects and maximize cellular uptake. The solution is prepared fresh and administered through standard IV access, with vital sign monitoring throughout the infusion. Subcutaneous injection offers a more convenient alternative, using small volumes (1-2ml) injected into fatty tissue of the abdomen or thigh. Some clinics offer intramuscular injection for intermediate bioavailability. Push IV (rapid injection) is generally avoided due to high incidence of nausea and flushing. Oral NAD+ has poor bioavailability, so most protocols use precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) that convert to NAD+ intracellularly. Combination approaches often use IV sessions 2-3 times weekly with oral precursors on off days.

Step-by-Step Guide

IV infusion remains the gold standard for NAD+ delivery, using slow infusion rates (typically 2-4 hours) to minimize side effects and maximize cellular uptake. The solution is prepared fresh and administered through standard IV access, with vital sign monitoring throughout the infusion. Subcutaneous injection offers a more convenient alternative, using small volumes (1-2ml) injected into fatty tissue of the abdomen or thigh. Some clinics offer intramuscular injection for intermediate bioavailability. Push IV (rapid injection) is generally avoided due to high incidence of nausea and flushing. Oral NAD+ has poor bioavailability, so most protocols use precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) that convert to NAD+ intracellularly. Combination approaches often use IV sessions 2-3 times weekly with oral precursors on off days.

Clinical Administration Guidelines

Injection Protocol

  • Subcutaneous injection per protocol
  • Rotate injection sites
  • Consistent daily timing
  • Follow protocol guidelines

Monitoring Schedule

  • Regular progress monitoring
  • Health parameter monitoring
  • Laboratory monitoring
  • Safety monitoring

Dosage Calculator

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Medical Disclaimer

NAD+ therapy is currently in research phase and not FDA-approved for specific medical conditions. This information is for educational purposes and should not replace consultation with qualified healthcare providers. Individual results may vary significantly. Professional medical supervision is recommended for all NAD+ therapeutic protocols.